Drug details:
Classification: Carbonyl compounds; Organooxygen compounds; Organic oxygen compounds; Organic compounds;

Curated SMILES: CC(=O)C1=CC=C(/C=C/C(=O)NC2=CC=C(C3=NC4=CC=C(C#N)C=C4N3O[Na+])C=C2)C=C1

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VF: TTSS (Type III secretion system)
Target: ExsA
Drug effect: Inhibits DNA binding by interacting specifically with the DNA-binding domain of ExsA and its homologs AscA, LscA, LcrF, ExsAvp (from Vibrio parahaemolyticus).
Max phase: Preclinical (in vitro)
Publication:
Marsden AE, et al., 2016. Inhibition of Pseudomonas aeruginosa ExsA DNA-Binding Activity by N-Hydroxybenzimidazoles. Antimicrob Agents Chemother 60(2):766-76.