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N-Isopropyl-2,3-dioxoindoline-1-acetamide

Drug details:
Molecular formula: C13H14N2O3

Classification: Amino acids, peptides, and analogues; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;
Synonym:  2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)-N-isopropylacetamide

Chemical structure:
Depiction based on curated SMILES O O CH 3 N O N H CH 3

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits a series of virulence factors such as quorum sensing, swarming and synthesis of pyocyanin, pyochelin and pyoverdine.
Max phase: Preclinical (in vitro)
Publication:
von Ambüren J, et al., 2020. Comprehensive Host Cell-Based Screening Assays for Identification of Anti-Virulence Drugs Targeting Pseudomonas aeruginosa and Salmonella Typhimurium. Microorganisms 8(8):1096.








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