Drug details:
Molecular formula: C₁₇H₁₆N₂O

Standard name: 3-(3,5-dimethylphenyl)imino-5-methyl-1H-indol-2-one

Synonyms:

(3E)-3-[(3,5-dimethylphenyl)imino]-5-methyl-1,3-dihydro-2H-indol-2-one 3-[(3,5-dimethylphenyl)imino]-5-methyl-1,3-dihydro-2H-indol-2-one

Curated SMILES: CC1=CC=C2NC(=O)/C(=N/C3=CC(C)=CC(C)=C3)C2=C1

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits a series of virulence factors such as quorum sensing, swarming and synthesis of pyocyanin, pyochelin and pyoverdine.
Max phase: Preclinical (in vitro)
Publication:
von Ambüren J, et al., 2020. Comprehensive Host Cell-Based Screening Assays for Identification of Anti-Virulence Drugs Targeting Pseudomonas aeruginosa and Salmonella Typhimurium. Microorganisms 8(8):1096.