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2-[(5-nitro-1H-benzimidazol-2-yl)sulfanyl]-N-[4-(trifluoromethoxy)phenyl]acetamide

Drug details:
Molecular formula: C16H11F3N4O4S

Classification: Benzimidazoles; Organoheterocyclic compounds; Organic compounds;
Synonyms:  2-[(5-nitro-1H-1,3-benzimidazol-2-yl)sulfanyl]-N~1~-[4-(trifluoromethoxy)phenyl]acetamide
2-[(5-nitro-1H-benzimidazol-2-yl)thio]-N-[4-(trifluoromethoxy)phenyl]acetamide

Chemical structure:
Depiction based on curated SMILES F F F O HN N H O _ O O + N N S

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: MvfR
Drug effect: Inhibits MvfR-regulated virulence functions.
Max phase: Preclinical (in vitro)
Publication:
Starkey M, et al., 2014. Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity. PLoS Pathog 10(8):e1004321.








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