Drug details:
Molecular formula: C₄H₁₁N₅

Standard name: 3-(diaminomethylidene)-1,1-dimethylguanidine

Synonyms:

1,1-Dimethylbiguanide N,N-dimethylimidodicarbonimidic diamide Fluamine Metiguanide Dimethylbiguanide Haurymelin Metformine Flumamine Gliguanid ......

Curated SMILES: CN(C)C(=N)N=C(N)N

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VF: Quorum sensing
Target: LasR
Drug effect: Inhibits a series of virulence factors such as quorum sensing, swarming and synthesis of pyocyanin, pyochelin and pyoverdine.
Max phase: Preclinical (in vitro)
Publication:
Abbas HA, et al., 2017. Repurposing metformin as a quorum sensing inhibitor in Pseudomonas aeruginosa. Afr Health Sci 17(3):808-819.