Drug details:
Molecular formula: C₁₇H₂₅ClN₂O₄S

Standard name: 11-chloro-12-isothiocyanato-3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide

Curated SMILES: O=C(CCCCCCCC(Cl)CN=C=S)CC(=O)NC1CCOC1=O

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VF: Quorum sensing
Target: LasR
Drug effect: Inhibits Quorum sensing and concomitant reduction of the virulence factor pyocyanin, as well as biofilm production by competing with AI molecule C12 binding to lasR N-terminal domain.
Max phase: Preclinical (in vivo)
Publication:
Amara N, et al., 2016. Fine-Tuning Covalent Inhibition of Bacterial Quorum Sensing. Chembiochem 17(9):825-35.