Drug details:
Molecular formula: C₁₆H₁₂O₅

Standard name: 5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one

Synonyms:

Biochanin 4'-Methylgenistein 5,7-Dihydroxy-4'-methoxyisoflavone 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one olmelin Pratensol Biochanine A Genistein 4-methyl ether 5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one ......

Curated SMILES: COC1=CC=C(C2=COC3=C(C2=O)C(O)=CC(O)=C3)C=C1

Evidence for compound's anti-virulence activity:

Clostridium
Related VF: Collagenase
Target: ColA
Drug effect: Inhibits collagenase activity to block the colonization and infiltration of the host by the bacteria.
Max phase: Preclinical (in vitro)
Publication:
Nitulescu G, et al., 2022. Discovery of New Microbial Collagenase Inhibitors. Life (Basel) 12(12):2114.

Staphylococcus
Related VFcategory: Others; Adherence; Biofilm
Target: SrtA
Drug effect: Inhibits bioflm formation by disturbing the adhesion mediated by SrtA.
Max phase: Preclinical (in vitro)
Publication:
Bai X, et al., 2023. Anti-biofilm activity of biochanin A against Staphylococcus aureus. Appl Microbiol Biotechnol 107(2-3):867-879.