Drug details:
Molecular formula: C₁₅H₁₂O₂

Standard name: (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

Synonyms:

o-Hydroxychalcone (E)-2'-Hydroxychalcone 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one Chalcone, 2'-hydroxy- 1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (2E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one Acrylophenone, 2'-hydroxy-3-phenyl- 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone ......

Curated SMILES: C1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2O

Evidence for compound's anti-virulence activity:

Clostridium
Related VF: Collagenase
Target: ColA
Drug effect: Inhibits collagenase activity to block the colonization and infiltration of the host by the bacteria.
Max phase: Preclinical (in vitro)
Publication:
Nitulescu G, et al., 2022. Discovery of New Microbial Collagenase Inhibitors. Life (Basel) 12(12):2114.