Drug details:
Molecular formula: C₂₃H₁₇NO₂S

Standard name: 11-(3-methoxyphenyl)-5,11-dihydroindeno[2,1-c][1,5]benzothiazepin-12-one

Synonyms:

6-(3-methoxyphenyl)-6,12-dihydro-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-5-one 11-(3-methoxyphenyl)-5,11-dihydroindeno[2,1-c][1,5]benzothiazepin-12-one 6-(3-methoxyphenyl)-6,12-dihydro-7H-indeno[2,1-c][1,5]benzothiazepin-7-one

Curated SMILES: COC1=CC(C2SC3=C(C=CC=C3)NC3=C2C(=O)C2=CC=CC=C23)=CC=C1

Evidence for compound's anti-virulence activity:

Clostridium
Related VF: TcdB (Toxin B)
Target: Calcium channels on the plasma membrane
Drug effect: Disrupts of TcdB-induced calcium signaling thus to ablate ROS production and prevent subsequent necrosis.
Max phase: Preclinical (in vitro)
Publication:
Farrow MA, et al., 2020. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chem Biol 15(5):1212-1221.