Drug details:
Molecular formula: C₁₇H₁₆BrN₃O₂S

Standard name: 5-acetyl-3-amino-4-(4-bromophenyl)-6-methyl-4,7-dihydrothieno[2,3-b]pyridine-2-carboxamide

Curated SMILES: CC(=O)C1=C(C)NC2=C(C(N)=C(C(N)=O)S2)C1C1=CC=C(Br)C=C1

Evidence for compound's anti-virulence activity:

Clostridium
Related VF: TcdB (Toxin B)
Target: Calcium channels on the plasma membrane
Drug effect: Disrupts of TcdB-induced calcium signaling thus to ablate ROS production and prevent subsequent necrosis.
Max phase: Preclinical (in vitro)
Publication:
Farrow MA, et al., 2020. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chem Biol 15(5):1212-1221.