Drug details:
Molecular formula: C₂₄H₂₀FNO₂

Standard name: 10-(3-fluorophenyl)-7,7-dimethyl-5,6,8,10-tetrahydroindeno[1,2-b]quinoline-9,11-dione

Synonym:

10-(3-fluorophenyl)-9-hydroxy-7,7-dimethyl-6,7,8,10-tetrahydro-11H-indeno[1,2-b]quinolin-11-one

Curated SMILES: CC1(C)CC2=NC3=C(C(=O)C4=C3C=CC=C4)C(C3=CC=CC(F)=C3)C2=C(O)C1

Evidence for compound's anti-virulence activity:

Clostridium
Related VF: TcdB (Toxin B)
Target: Calcium channels on the plasma membrane
Drug effect: Disrupts of TcdB-induced calcium signaling thus to ablate ROS production and prevent subsequent necrosis.
Max phase: Preclinical (in vitro)
Publication:
Farrow MA, et al., 2020. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chem Biol 15(5):1212-1221.