Drug details:
Molecular formula: C₂₀H₁₉FN₄O₃

Standard name: 7-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-5-nitroquinolin-8-ol

Curated SMILES: O=[N+]([O-])C1=CC(CN2CCN(C3=CC=C(F)C=C3)CC2)=C(O)C2=NC=CC=C12

Evidence for compound's anti-virulence activity:

Chlamydia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Inhibits T3SS activity.
Max phase: Preclinical (in vitro)
Publication:
Enquist PA, et al., 2012. Derivatives of 8-hydroxyquinoline--antibacterial agents that target intra- and extracellular Gram-negative pathogens. Bioorg Med Chem Lett 22(10):3550-3.

Yersinia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Inhibits T3SS.
Max phase: Preclinical (in vitro)
Publication:
Enquist PA, et al., 2012. Derivatives of 8-hydroxyquinoline--antibacterial agents that target intra- and extracellular Gram-negative pathogens. Bioorg Med Chem Lett 22(10):3550-3.