Drug details:
Classification: Lipoamides; Dithiolanes; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: O=C(O)CCCN1C(=O)C2=CC=C(NCCCCCCCCNC(=O)CCCCC3CCSS3)C3=CC=CC(=C23)C1=O

Evidence for compound's anti-virulence activity:

Vibrio
Related VF: TCP (Toxin-coregulated pilus)
Target: TcpN/ToxT
Drug effect: Inhibits the dimerization of the transcriptional activator ToxT thus to prevent expression of two critical V. cholerae virulence factors, CT and the TCP.
Max phase: Preclinical (in vitro)
Publication:
Jana SK, et al., 2021. Virstatin-Conjugated Gold Nanoparticle with Enhanced Antimicrobial Activity against the Vibrio cholerae El Tor Biotype. ACS Appl Bio Mater 4(4):3089-3100.