Drug details:
Molecular formula: C₁₅H₁₂O₃

Standard name: (E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one

Synonyms:

1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one (E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one CHALCONE, 2',4'-DIHYDROXY- (E)-2',4'-Dihydroxychalcone 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl- 1-(2,4-Dihydroxyphenyl)-3-phenyl-2-propen-1-one 1-(2,4-Dihydroxy-phenyl)-3-phenyl-propenone Chalcone,4'-dihydroxy- 2-Benzylidene-2',4'-dihydroxyacetophenone ......

Curated SMILES: O=C(/C=C/C1=CC=CC=C1)C1=CC=C(O)C=C1O

Evidence for compound's anti-virulence activity:

Vibrio
Related VF: HlyU
Target: HlyU
Drug effect: Targets the HlyU and reduces the virulence and infection.
Max phase: Preclinical (in vivo)
Publication:
Imdad S, et al., 2018. Identification of 2',4'-Dihydroxychalcone as an Antivirulence Agent Targeting HlyU, a Master Virulence Regulator in Vibrio vulnificus. Molecules 23(6):1492.