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E676-4861

Drug details:
Molecular formula: C20H25N3O2S

Classification: Benzothiazoles; Organoheterocyclic compounds; Organic compounds;
Synonym:  N-[2-(diethylamino)ethyl]-N-(4,5-dimethyl-1,3-benzothiazol-2-yl)-2-furamide

Chemical structure:
Depiction based on curated SMILES O O H 3 C CH 3 CH 3 S N N H 3 C N

Evidence for compound's anti-virulence activity:

Vibrio
Related VFcategory: Stress survival
Target: Not determined
Drug effect: Inhibits σE stress response pathway of Vibrio cholerae that is required for full virulence of the organism.
Max phase: Preclinical (in vitro)
Publication:
Stanbery L, et al., 2017. Assay development and high-throughput screening for small molecule inhibitors of a Vibrio cholerae stress response pathway. Drug Des Devel Ther 11:2777-2785.








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