Drug details:
Molecular formula: C₁₆H₁₈O₉

Standard name: (1S,3R,4R,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid

Synonyms:

3-O-Caffeoylquinic acid Heriguard Chlorogenate 3-(3,4-Dihydroxycinnamoyl)quinic acid 3-Caffeoylquinic acid Hlorogenic acid trans-Chlorogenic acid CP chlorogenic acid Caffeoyl quinic acid ......

Curated SMILES: C1C(C(C(CC1(C(=O)O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O

Evidence for compound's anti-virulence activity:

Klebsiella
Related VFcategory: Biofilm; Biofilm
Target: Not determined
Drug effect: Downregulates two biofilm-associated genes (type 3 fimbriae mrkD and trehalose-6-phosphate hydrolase treC), inhibits AI-2 activity and biofilm formation.
Max phase: Preclinical (in vivo)
Publications:
Rajasekharan SK, et al., 2017. Antibiofilm and Anti-beta-Lactamase Activities of Burdock Root Extract and Chlorogenic Acid against Klebsiella pneumoniae. J Microbiol Biotechnol 27(3):542-551.
Wang L, et al., 2022. Effects of chlorogenic acid on antimicrobial, antivirulence, and anti-quorum sensing of carbapenem-resistant Klebsiella pneumoniae. Front Microbiol 13:997310.