Drug details:
Molecular formula: C₆H₈O₆

Standard name: (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one

Synonyms:

ascorbic acid vitamin C ascorbate L(+)-Ascorbic acid L-ascorbate Ascoltin Ascorbicap Cevitamic acid Hybrin ......

Curated SMILES: C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O

Evidence for compound's anti-virulence activity:

Klebsiella
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Induces reactive oxygen species generation, acts as an efflux pumper inhibitor to disrupt transportation of EPS and capsular polysaccharide and suppresses the production of exopolysaccaride thereby inhibiting biofilm formation.
Max phase: Preclinical (in vivo)
Publication:
Xu C, et al., 2022. Bactericidal, anti-biofilm, and anti-virulence activity of vitamin C against carbapenem-resistant hypervirulent Klebsiella pneumoniae. iScience 25(3):103894.