Drug details:
Molecular formula: C₁₃H₁₄N₂O

Standard name: 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole

Synonyms:

Dihydroharmine Harmidine Armalin Harmalol methyl ether O-Methylharmalol 3,4-Dihydroharmine Harmine, dihydro- 3H-Pyrido[3,4-b]indole, 4,9-dihydro-7-methoxy-1-methyl- 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole ......

Curated SMILES: CC1=NCCC2=C1NC3=C2C=CC(=C3)OC

Evidence for compound's anti-virulence activity:

Escherichia
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation and reduces fimbriae production and swarming and swimming motilities.
Max phase: Preclinical (in vitro)
Publication:
Lee JH, et al., 2017. Antibiofilm activities of norharmane and its derivatives against Escherichia coli O157:H7 and other bacteria. Phytomedicine 36:254-261.

Klebsiella
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Lee JH, et al., 2017. Antibiofilm activities of norharmane and its derivatives against Escherichia coli O157:H7 and other bacteria. Phytomedicine 36:254-261.

Pseudomonas
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Lee JH, et al., 2017. Antibiofilm activities of norharmane and its derivatives against Escherichia coli O157:H7 and other bacteria. Phytomedicine 36:254-261.