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Fascioquinol E

Drug details:
Molecular formula: C26H38O5S

Classification: Diterpenoids; Prenol lipids; Lipids and lipid-like molecules; Organic compounds;
Chemical structure:
Depiction based on curated SMILES H 3 C H 3 C H 3 C H 3 C HO OH O O S O H 3 C

Evidence for compound's anti-virulence activity:

Streptococcus
Related VFcategory: Immune modulation
Target: CpsB
Drug effect: Inhibits CpsB phosphatase activity to decrease capsule synthesis.
Max phase: Preclinical (in vivo)
Publication:
Standish AJ, et al., 2012. Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production. PLoS One 7(5):e36312.








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