Streptococcus
Related VFcategory: Immune modulation
Target: CpsB
Drug effect: Inhibits CpsB phosphatase activity to decrease capsule synthesis.
Max phase: Preclinical (in vivo)
Publication: Standish AJ, et al., 2012. Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production. PLoS One 7(5):e36312.