Drug details:
Molecular formula: C₂₃H₄₄N₄O

Standard name: 4-(2-amino-1H-imidazol-5-yl)-N-hexadecylbutanamide

Curated SMILES: CCCCCCCCCCCCCCCCNC(=O)CCCC1=CNC(N)=N1

Evidence for compound's anti-virulence activity:

Streptococcus
Related VFcategory: Biofilm
Target: VicR
Drug effect: Binds to VicR and inhibits expression of vicR and VicR-regulated genes, including the genes that encode the key biofilm matrix producing enzymes, Gtfs in S.mutans.
Max phase: Preclinical (in vivo)
Publication:
Liu C, et al., 2023. Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. mBio 14(3):e0013723.