Drug details:
Molecular formula: C₃₂H₂₂O₁₀

Standard name: 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one

Synonyms:

7,4'-Dimethylamentoflavone Amentoflavone 7,4'-dimethyl ether 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)- 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Ginkgetin 7''-O-beta-D-glucopyranoside 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-chromen-2-yl)-2-methoxy-phenyl]-2-(4-hydroxyphenyl)chromen-4-one ......

Curated SMILES: COC1=CC2=C(C(=O)C=C(C3=CC=C(OC)C(C4=C(O)C=C(O)C5=C4OC(C4=CC=C(O)C=C4)=CC5=O)=C3)O2)C(O)=C1

Evidence for compound's anti-virulence activity:

Streptococcus
Related VF: Suilysin
Target: Sly
Drug effect: Suppresses the process of oligomerization to inhibit Suilysin activity.
Max phase: Preclinical (in vivo)
Publication:
Li G, et al., 2019. Ginkgetin in vitro and in vivo reduces Streptococcus suis virulence by inhibiting suilysin activity. J Appl Microbiol 127(5):1556-1563.