Drug details:
Molecular formula: C₁₆H₁₂O₅

Standard name: 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one

Synonyms:

Linarigenin 5,7-Dihydroxy-4'-methoxyflavone 4'-Methoxyapigenin Buddleoflavonol Acacetine 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one Linarisenin Apigenin 4'-methyl ether Akatsetin ......

Curated SMILES: COC1=CC=C(C2=CC(=O)C3=C(O)C=C(O)C=C3O2)C=C1

Evidence for compound's anti-virulence activity:

Listeria
Related VF: LLO (Listeriolysin O)
Target: Hly
Drug effect: Inhibits LLO pore formation.
Max phase: Preclinical (in vivo)
Publication:
Li S, et al., 2022. Acacetin Alleviates Listeria monocytogenes Virulence Both In Vitro and In Vivo via the Inhibition of Listeriolysin O. Foodborne Pathog Dis 19(2):115-125.

Streptococcus
Related VF: Pneumolysin
Target: Ply
Drug effect: Suppresses the pore-forming activity of Pneumolysin by inhibiting oligomerization of Pneumolysin.
Max phase: Preclinical (in vivo)
Publication:
Li S, et al., 2020. Acacetin inhibits Streptococcus pneumoniae virulence by targeting pneumolysin. J Pharm Pharmacol 72(8):1092-1100.