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Bis(carboxycyclopentadienyl) Iron

Drug details:
Molecular formula: C12H10FeO4

Classification: Carboxylic acids; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;
Synonyms:  Cyclopentanecarboxylic acid
iron
1-1'-FERROCENEDICARBOXYLIC ACID

Chemical structure:
Depiction based on curated SMILES _ 2+ Fe HO O H _ HO O H

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vivo)
Publication:
Liang F, et al., 2003. Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. J Biol Chem 278(43):41734-41.








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