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2-hydroxy-5-{5-[(E)-{2-[(5-phenyl-2H-tetrazol-2-yl)acetyl]hydrazinylidene}methyl]furan-2-yl}benzoic acid

Drug details:
Molecular formula: C21H16N6O5

Classification: Tetrazoles; Azoles; Organoheterocyclic compounds; Organic compounds;
Chemical structure:
Depiction based on curated SMILES OH O HO O N N H O N N N N

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vitro)
Publication:
Tautz L, et al., 2005. Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J Biol Chem 280(10):9400-8.








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