Drug details:
Molecular formula: C₁₅H₁₀Cl₃NO₂

Standard name: 1-[4-chloro-3-[(3,5-dichloro-2-hydroxyphenyl)methylideneamino]phenyl]ethanone

Curated SMILES: CC(=O)C1=CC=C(Cl)C(/N=C/C2=CC(Cl)=CC(Cl)=C2O)=C1

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Having a significant and dramatic effect on the expression of Ler-dependent genes that encode virulence factors within (EspB, Tir, type III apparatus) and outside (EspC) the LEE.
Max phase: Preclinical (in vitro)
Publication:
Gauthier A, et al., 2005. Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli. Antimicrob Agents Chemother 49(10):4101-9.