Drug details:
Molecular formula: C₄₄H₆₂N₂O₁₂

Standard name: (2S)-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-[(1E,3E,5E)-7-(4-hydroxy-1-methyl-2-oxopyridin-3-yl)-6-methyl-7-oxohepta-1,3,5-trienyl]oxolan-2-yl]-6-methoxy-5-methylocta-2,4-dienyl]-2-[(2R,3R,4R,6S)-2,3,4-trihydroxy-5,5-dimethyl-6-[(1E,3Z)-penta-1,3-dienyl]oxan-2-yl]butanamide

Synonyms:

Goldinomycin 1-Methylmocimycin Goldinodox Mocimycin, 1-methyl- N-METHYL KIRROMYCIN AURODOX [MI] AURODOX 1-METHYLMOCIMYCIN GOLDINODOX ......

Curated SMILES: CC[C@H](C(=O)NC/C=C/C=C(\C)/[C@H]([C@@H](C)[C@H]1[C@H]([C@H]([C@H](O1)/C=C/C=C/C=C(\C)/C(=O)C2=C(C=CN(C2=O)C)O)O)O)OC)[C@@]3([C@@H]([C@@H](C([C@@H](O3)/C=C/C=C\C)(C)C)O)O)O

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Inhibited the secretion of some LEE-encoded proteins (EspA, EspB, EspD, EspF and Map) and EspC.
Max phase: Preclinical (in vivo)
Publication:
Kimura K, et al., 2011. A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium. J Antibiot (Tokyo) 64(2):197-203.