Escherichia
Related VF: Type 1 fimbriae
Target: FimH
Drug effect: Bound to the FimH lectin domain to interfere with bacterial adhesion, invasion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication: Cusumano CK, et al., 2011. Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Sci Transl Med 3(109):109ra115.