Drug details:
Molecular formula: C₁₅H₁₉BN₂O₂

Standard name: 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-amine

Curated SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC3=C(C=C2)C=CN=C3N

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: Type 1 fimbriae
Target: FimH
Drug effect: Bound to the FimH lectin domain to interfere with bacterial adhesion, invasion and biofilm formation.
Max phase: Preclinical (in vivo)
Publication:
Mydock-McGrane L, et al., 2016. Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections. J Med Chem 59(20):9390-9408.