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[3,4,5-triacetyloxy-6-[2-methyl-4-[3-(methylcarbamoyl)phenyl]phenoxy]oxan-2-yl]methyl acetate

Drug details:
Molecular formula: C29H33NO11

Classification: Tetracarboxylic acids and derivatives; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;
Chemical structure:
Depiction based on curated SMILES O O CH 3 O O CH 3 O CH 3 O CH 3 NH O H 3 C O O O CH 3 O

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: Type 1 fimbriae
Target: FimH
Drug effect: Bound to the FimH lectin domain to interfere with bacterial adhesion, invasion and biofilm formation.
Max phase: Preclinical (in vivo)
Publication:
Mydock-McGrane L, et al., 2016. Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections. J Med Chem 59(20):9390-9408.








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