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Guadinomine A

Drug details:
Molecular formula: C20H38N8O8

Classification: Amino acids, peptides, and analogues; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;
Chemical structure:
Depiction based on curated SMILES H 2 N N N O NH 2 OH OH OH NH 2 NH 2 H 3 C H O N H H CH 3 CH 3 O HO N H O

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Markedly inhibit EPEC-induced hemolysis.
Max phase: Preclinical (in vitro)
Publication:
Iwatsuki M, et al., 2008. Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. I: taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo) 61(4):222-9.








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