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Guadinomine C1

Drug details:
Molecular formula: C23H40N8O8

Classification: Amino acids, peptides, and analogues; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;
Chemical structure:
Depiction based on curated SMILES H 3 C O OH H H H 3 C H N N NH 2 O H 2 N OH HO O H O N H H H N H H 3 C NH H CH 3 O N H H

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Markedly inhibit EPEC-induced hemolysis.
Max phase: Preclinical (in vitro)
Publication:
Iwatsuki M, et al., 2008. Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. I: taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo) 61(4):222-9.








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