Drug details:
Molecular formula: C₉H₈O

Standard name: (E)-3-phenylprop-2-enal

Synonyms:

trans-Cinnamaldehyde Cinnamic aldehyde 3-Phenylacrylaldehyde (E)-Cinnamaldehyde Cinnamal Zimtaldehyde 2-Propenal, 3-phenyl- (2E)-3-phenylprop-2-enal 3-Phenylpropenal ......

Curated SMILES: C1=CC=C(C=C1)C=CC=O

Evidence for compound's anti-virulence activity:

Enterococcus
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Antibiofilm effects primarily by targeting the biofilm cells without degrading the matrix and prevents biofilm recovery after treatment.
Max phase: Preclinical (in vitro)
Publication:
Ali IAA, et al., 2020. Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery. Microb Pathog 149:104482.