Drug details:
Molecular formula: C₂₀H₁₈NO₄⁺

Standard name: 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene

Synonyms:

Umbellatine Berberin Berbericine Majarine Thalsine Umbellatin Berberone Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy- EINECS 218-229-1 ......

Curated SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

Evidence for compound's anti-virulence activity:

Enterococcus
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Effectively prevents biofilm formation and promotes biofilm dispersion, most likely by inhibiting the expression of sortase A and esp.
Max phase: Preclinical (in vitro)
Publication:
Chen L, et al., 2016. The effect of berberine hydrochloride on Enterococcus faecalis biofilm formation and dispersion in vitro. Microbiol Res 0:44-51.