Drug details:
Molecular formula: C₂₂H₁₈O₁₁

Standard name: [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate

Synonyms:

(-)-Epigallocatechin gallate Epigallocatechin gallate Epigallocatechin 3-gallate Tea catechin Teavigo Epigallocatechin-3-monogallate (-)-Epigallocatechin-3-o-gallate (-)-epigallocatechin 3-gallate (-)-Epigallocatechol gallate ......

Curated SMILES: C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

Evidence for compound's anti-virulence activity:

Burkholderia
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Interferes with bacterial quorum-sensing.
Max phase: Preclinical (in vitro)
Publication:
Huber B, et al., 2003. Influence of polyphenols on bacterial biofilm formation and quorum-sensing. Z Naturforsch C J Biosci 58(11-12):879-84.

Enterococcus
Related VFcategory: Biofilm; Others
Target: Not determined
Drug effect: Inhibits bacterial growth and suppresses the expression of specific genes related to virulence and biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Lee P, et al., 2015. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol 60(3):393-9.

Escherichia
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation and swarm motility, and reduces the expression of virulence genes regulated by QS.
Max phase: Preclinical (in vitro)
Publications:
Huber B, et al., 2003. Influence of polyphenols on bacterial biofilm formation and quorum-sensing. Z Naturforsch C J Biosci 58(11-12):879-84.
Lee KM, et al., 2009. Antipathogenic properties of green tea polyphenol epigallocatechin gallate at concentrations below the MIC against enterohemorrhagic Escherichia coli O157:H7. J Food Prot 72(2):325-31.

Pseudomonas
Related VF: Quorum sensing
Target: Not determined
Drug effect: Inhibits biofilm formation and swarm motility,and reduces the expression of virulence genes regulated by QS.
Max phase: Preclinical (in vitro)
Publication:
Huber B, et al., 2003. Influence of polyphenols on bacterial biofilm formation and quorum-sensing. Z Naturforsch C J Biosci 58(11-12):879-84.