Drug details:
Molecular formula: C₁₅H₁₄O₃

Standard name: 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione

Synonyms:

lapachone 2,2-Dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione .beta.-Lapachone Lapachone, beta- 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-B]pyran-5,6-dione Beta-lap-wj 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione ARQ-501 (beta lapachone) ......

Curated SMILES: CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C

Evidence for compound's anti-virulence activity:

Helicobacter
Related VF: Flagella
Target: Not determined
Drug effect: Inhibits motility and flagellar assembly.
Max phase: Preclinical (in vitro)
Publication:
Suerbaum S, et al., 2022. Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model. mBio 13(2):e0375521.