Drug details:
Molecular formula: C₃₀H₁₈O₁₀

Standard name: 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

Synonyms:

Didemethyl-ginkgetin 3',8''-Biapigenin Amenthoflavone I3,II8-biapigenin Tridemethylsciadopitysin 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)- 8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one ......

Curated SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O

Evidence for compound's anti-virulence activity:

Helicobacter
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Reduces the biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Spiegel M, et al., 2021. In Silico Screening and In Vitro Assessment of Natural Products with Anti-Virulence Activity against Helicobacter pylori. Molecules 27(1):20.

Listeria
Related VF: LLO (Listeriolysin O)
Target: Hly
Drug effect: Inhibits LLO pore formation.
Max phase: Preclinical (in vivo)
Publication:
Tingting W, et al., 2022. Amentoflavone attenuates Listeria monocytogenes pathogenicity through an LLO-dependent mechanism. Br J Pharmacol 179(14):3839-3858.