Drug details:
Molecular formula: C₂₈H₃₈N₂O₉S

Standard name: 2-[[3,5-bis(2-methoxyethoxy)benzoyl]amino]ethyl (2S)-1-benzylsulfonylpiperidine-2-carboxylate

Curated SMILES: COCCOC1=CC(=CC(=C1)C(=O)NCCOC(=O)C2CCCCN2S(=O)(=O)CC3=CC=CC=C3)OCCOC

Evidence for compound's anti-virulence activity:

Burkholderia
Related VFcategory: Others
Target: MIP
Drug effect: Inhibits the PPIase activity of Mip proteins and reduces the intracellular burden.
Max phase: Preclinical (in vitro)
Publication:
Iwasaki J, et al., 2022. Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major. J Antimicrob Chemother 77(6):1625-1634.

Neisseria
Related VFcategory: Others
Target: Mip
Drug effect: Inhibits the PPIase activity of Mip proteins and reduces the intracellular burden.
Max phase: Preclinical (in vitro)
Publication:
Iwasaki J, et al., 2022. Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major. J Antimicrob Chemother 77(6):1625-1634.