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lithium;(3R)-8-cyclopropyl-5-oxo-7-(quinolin-3-ylmethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylate

Drug details:
Molecular formula: C21H17LiN2O3S

Classification: Amino acids, peptides, and analogues; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;
Chemical structure:
Depiction based on curated SMILES N O + Li _ O O S H N

Evidence for compound's anti-virulence activity:

Listeria
Related VF: PrfA (Pleiotropic regulatory factor)
Target: PrfA
Drug effect: Binds to PrfA, the master virulence regulator to decrease virulence factor expression.
Max phase: Preclinical (in vitro)
Publication:
Kulén M, et al., 2018. Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes. J Med Chem 61(9):4165-4175.








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