Drug details:
Molecular formula: C₁₃H₁₆N₂O

Standard name: 2-(butylamino)quinolin-8-ol

Synonyms:

2-(BUTYLAMINO)-8-QUINOLINOL 8-Quinolinol, 2-(butylamino)-

Curated SMILES: CCCCNC1=NC2=C(C=CC=C2O)C=C1

Evidence for compound's anti-virulence activity:

Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publications:
Paschos A, et al., 2011. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun 79(3):1033-43.
Smith MA, et al., 2012. Identification of the binding site of Brucella VirB8 interaction inhibitors. Chem Biol 19(8):1041-8.