Drug details:
Molecular formula: C₁₀H₉N₃O₂S

Standard name: 6-benzylsulfanyl-2H-1,2,4-triazine-3,5-dione

Synonyms:

5-(Benzylthio)-6-azauracil 6-(Benzylthio)-as-triazine-3,5(2H,4H)-dione 5-Benzylthio-6-azauracil 6-Benzylsulfanyl-2H-[1,2,4]triazine-3,5-dione 6-(benzylsulfanyl)-1,2,4-triazine-3,5-diol 6-(benzylsulfanyl)-1,2,4-triazine-3,5(2H,4H)-dione 6-((PHENYLMETHYL)THIO)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE 1,2,4-TRIAZINE-3,5(2H,4H)-DIONE, 6-((PHENYLMETHYL)THIO)-

Curated SMILES: C1=CC=C(C=C1)CSC2=NNC(=O)NC2=O

Evidence for compound's anti-virulence activity:

Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publication:
Paschos A, et al., 2011. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun 79(3):1033-43.