Drug details:
Molecular formula: C₉H₅N₃O₅

Standard name: 5,7-dinitroquinolin-8-ol

Synonyms:

5,7-Dinitro-8-quinolinol 8-Quinolinol, 5,7-dinitro- 8-Quinolinol,5,7-dinitro- 8-Quinolinol,5,7-dinitro 5,7-Bis(hydroxyl[oxido]amino)-8-hydroxyquinoline 5,7-Dinitro-8-hydroxyquinoline 5,7-Dinitrooxine 8-Hydroxy-5,7-dinitroquinoline 5,7-dinitro-8-hydroxyquinoline

Curated SMILES: O=[N+]([O-])C1=CC([N+](=O)[O-])=C(O)C2=C1C=CC=N2

Evidence for compound's anti-virulence activity:

Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publication:
Paschos A, et al., 2011. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun 79(3):1033-43.