Drug details:
Molecular formula: C₁₀H₁₀O₂

Standard name: 2-hydroxy-3-prop-1-en-2-ylcyclohepta-2,4,6-trien-1-one

Synonyms:

2-Hydroxy-3-(Prop-1-En-2-Yl)cyclohepta-2,4,6-Trien-1-One 2-HYDROXY-3-ISOPROPENYL-2,4,6-CYCLOHEPTATRIEN-1-ONE 2-hydroxy-3-prop-1-en-2-ylcyclohepta-2,4,6-trien-1-one

Curated SMILES: C=C(C)C1=C(O)C(=O)C=CC=C1

Evidence for compound's anti-virulence activity:

Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publication:
Paschos A, et al., 2011. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun 79(3):1033-43.