Drug details:
Molecular formula: C₇H₇ClNa₂O₆P₂S

Standard name: disodium;[(4-chlorophenyl)sulfanyl-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

Synonyms:

Tiludronic acid disodium salt Skelid sr 41319b Tiludronate sodium Disodium Tiludronate Tiludronate disodium [USAN] Tiludronate disodium anhydrous TILUDRONIC ACID, DISODIUM SALT Tiludronic Acid (disodium) ......

Curated SMILES: C1=CC(=CC=C1SC(P(=O)(O)[O-])P(=O)(O)[O-])Cl.[Na+].[Na+]

Evidence for compound's anti-virulence activity:

Bacillus
Related VF: Collagenase
Target: ColQ1;ColA
Drug effect: Binds to bacterial collagenase to inhibit their activity thus to maintain the cell attachment, cell morphology, and cell viability.
Max phase: Preclinical (in vitro)
Publication:
Alhayek A, et al., 2022. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65(19):12933-12955.

Clostridium
Related VF: Collagenase
Target: ColG;ColH
Drug effect: Binds to bacterial collagenase to inhibit their activity thus to maintain the cell attachment, cell morphology, and cell viability.
Max phase: Preclinical (in vitro)
Publication:
Alhayek A, et al., 2022. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65(19):12933-12955.