Drug details:
Molecular formula: C₄H₁₂NNaO₇P₂

Standard name: sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate

Synonyms:

Fosamax Binosto Fosamac Onclast alendronate monosodium Monosodium alendronate Osteovan Indrol Alend ......

Curated SMILES: C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.[Na+]

Evidence for compound's anti-virulence activity:

Bacillus
Related VF: Collagenase
Target: ColQ1;ColA
Drug effect: Binds to bacterial collagenase to inhibit their activity thus to maintain the cell attachment, cell morphology, and cell viability.
Max phase: Preclinical (in vitro)
Publication:
Alhayek A, et al., 2022. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65(19):12933-12955.

Clostridium
Related VF: Collagenase
Target: ColG;ColH
Drug effect: Binds to bacterial collagenase to inhibit their activity thus to maintain the cell attachment, cell morphology, and cell viability.
Max phase: Preclinical (in vitro)
Publication:
Alhayek A, et al., 2022. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65(19):12933-12955.