Drug details:
Classification: Amino acids, peptides, and analogues; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;

Curated SMILES: O=C1CNC(=O)C(C2=CC(OCC3=CC=CC=C3)=CC=C2OCC2=CC=CC=C2)N1

Evidence for compound's anti-virulence activity:

Burkholderia
Related VF: Quorum-sensing
Target: CepI
Drug effect: Inhibits acyl-HSL synthase CepI activity.
Max phase: Preclinical (in vivo)
Publication:
Scoffone VC, et al., 2016. Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo. Sci Rep 6:32487.