Drug details:
Molecular formula: C₉H₆O₃

Standard name: 7-hydroxychromen-2-one

Synonyms:

7-hydroxycoumarin 7-Hydroxy-2H-chromen-2-one Hydrangin Skimmetin 7-hydroxycoumarine Hydrangine Skimmetine 7-Oxycoumarin Umbelliferon ......

Curated SMILES: C1=CC(=CC2=C1C=CC(=O)O2)O

Evidence for compound's anti-virulence activity:

Aeromonas
Related VF: WhiB3
Target: Not determined
Drug effect: Inhibits A. hydrophila virulence such as hemolysis, biofilm formation, swimming and swarming motility, and their quorum-sensing signals AHL and AI-2; downregulats expression levels of genes related to exotoxin, the secretory systems (T2SS and T6SS), iron uptake, and etc.
Max phase: Preclinical (in vitro)
Publication:
Zhao L, et al., 2022. The Antivirulence Activity of Umbelliferone and Its Protective Effect against A. hydrophila-Infected Grass Carp. Int J Mol Sci 23(19):11119.