Drug details:
Molecular formula: C₂₀H₁₄NO₄⁺

Standard name: 24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene

Synonyms:

Pseudochelerythrine Sanguinarin sangvinarin Veadent Sangrovit Dimethylenedioxy benzphenanthridine [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl- EINECS 219-503-3 Pseudochelerythrine ......

Curated SMILES: C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6

Evidence for compound's anti-virulence activity:

Aeromonas
Related VFcategory: Biofilm; Regulation
Target: Not determined
Drug effect: Inhibits the production of aerolysin and the biofilm formation by decreasing the expression of aerolysin encoding gene aerA, and quorum sensing genes ahyI and ahyR.
Max phase: Preclinical (in vivo)
Publication:
Zhang L, et al., 2022. Sanguinarine Protects Channel Catfish against Aeromonas hydrophila Infection by Inhibiting Aerolysin and Biofilm Formation. Pathogens 11(3):323.