Drug details:
Molecular formula: C₂₁H₂₂NO₄⁺

Standard name: 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium

Synonyms:

Berbericinine Palmatin O,O-Dimethyldemethyleneberberine Burasaine Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy- palmatine ion palmatine cation 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium 7,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxyberbinium ......

Curated SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC

Evidence for compound's anti-virulence activity:

Aeromonas
Related VF: Aerolysin
Target: Not determined
Drug effect: Reduces hemolysis of the bacterium by decreasing aerolysin production and suppresses the transcription of the aerA gene.
Max phase: Preclinical (in vivo)
Publication:
Dong J, et al., 2022. Palmatine Inhibits the Pathogenicity of Aeromonas hydrophila by Reducing Aerolysin Expression. Foods 11(20):3250.