Drug details:
Molecular formula: C₉H₁₀N₂O₃S₂

Standard name: 6-ethoxy-1,3-benzothiazole-2-sulfonamide

Synonyms:

6-Ethoxy-2-benzothiazolesulfonamide Ethoxyzolamide Ethoxazolamide Ethamide Cardrase Etoxzolamide Glaucotensil 6-Ethoxy-1,3-benzothiazole-2-sulfonamide Diuretic C ......

Curated SMILES: CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Regulation
Target: Carbonic anhydrase (CA)
Drug effect: Downregulates the core PhoPR regulon, alters accumulation of virulence-associated lipids, and inhibits Esx-1 protein secretion.
Max phase: Preclinical (in vivo)
Publication:
Johnson BK, et al., 2015. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence. Antimicrob Agents Chemother 59(8):4436-45.