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Gossypol acetic acid

Drug details:
Molecular formula: C32H34O10

Classification: Alcohols and polyols; Organooxygen compounds; Organic oxygen compounds; Organic compounds;
Synonyms:  gossypol-Acetic acid
Gossypol acetate
Acetate gossypol
Gossypol (acetic acid)
(S)-Gossypol (acetic acid)
(-)-Gossypol acetic acid
Gossypol acetate, (R)-
(R)-Gossypol acetic acid
Gossypol acetic acid, R-
......

Chemical structure:
Depiction based on curated SMILES OH H 3 C O OH H 3 C CH 3 OH OH CH 3 O HO CH 3 H 3 C CH 3 HO OH O

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Motility
Target: Not determined
Drug effect: Inhibits sliding motility and then results in a decrease in bacterial virulence.
Max phase: Preclinical (in vitro)
Publication:
Ouertatani-Sakouhi H, et al., 2017. Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model. PLoS One 12(7):e0181121.








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